Discussion on New Wine in a New Bottle.

You will prepare and submit a term paper on New Wine in a New Bottle. Your paper should be a minimum of 1750 words in length. The presence of alcohol inhibits this action of GABA. When this inhibition of GABA is continual, the receptor compensation is in the form of a reduction in the number of GABAA receptor subunits. Sedative drugs like benzodiazepines have the ability to bind to the chloride channel and cause GABA inhibition. It is this common mechanism in the action of alcohol and sedative-hypnotics that are responsible for the cross tolerance seen with these substances. Lead investigator Jing Ling and her colleagues at the University of California provide another step forward towards a better understanding of the mechanisms involved in ethanol abuse. Evidence from earlier studies has all pointed to acute ethanol intoxication enhancing the functioning of the GABAA receptor, while chronic intoxication results in GBAAR function. The subunit composition has a strong influence on the acute potentiation by ethanol with particular emphasis on A4BD GABAAR, which demonstrates a strong affinity for GABA, insensitivity to benzodiazepine, slow desensitizing kinetics and strong sensitivity to ethanol. There are suggestions that development of quick ethanol tolerance in rats and humans may stem from medication from medication from the functional changes in GABAARs. In this study, the investigators set out to find out whether the function and the subunit composition of GABAARs could be changed by just one intoxicating of ethanol and study the mechanisms involved in these changes with regard to the hippocampal CAI and dentate gyrus regions.
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